Nephro-Protective Trial: Amino Acid Infusion Protocol

If your site uses high protein EN (>55g/L) at slow constant rates for 'gut protection' when patients receive PN,
please use new NephroCalc here.
Click for help.Date and Time:
Click for help.Patient:     

Click for help.Weight:      kg       Click for help.Height:  cm

Click for help.EN Name:   Click for help.EN Bag Size: mLs
Click for help.EN Protein:  g/Bag Calculated EN Protein content: g/L

Click for help.PN Name:   Click for help.PN Bag Size: mLs
Click for help.PN Nitrogen: g/Bag Calculated PN Protein content: g/L
  Note: 1 g Nitrogen = 6.06 g Amino Acids, 1 g Amino Acids = 1 g Protein. To convert Protein to Nitrogen, divide Protein by 6.06.
Study Synthamin 17 EF does not count towards protein or nitrogen intake from PN.
Begin infusion within 1 hour of randomisation.

  • Commence Synthamin 17 EF at ml/hr continuously over 24 hrs via a central venous catheter. Note: Patient remains on this initial rate for entire ICU stay, unless threshold Nutrition Rate is exceeded.
  • This patient's maximum Synthamin 17 EF infusion rate is: mls/h.
  • Nutrition Rate is calculated at the bedside as the sum of the current EN delivery rate plus PN infusion rate, expressed in mls/hr. Glucose alone, Study Syntamin 17 EF and Propofol do not count as PN.
  • IF patients current Nutrition Rate exceeds the threshold Nutrition Rate, use the following table to reduce Synthamin 17 EF infusion rates:

    Nutrition Rate exceeds:ml/hr change Synthamin 17 EF to:ml/hr

    Nutrition Rate exceeds:ml/hr change Synthamin 17 EF to:ml/hr

    Nutrition Rate exceeds:ml/hr change Synthamin 17 EF to:ml/hr

    Nutrition Rate exceeds:ml/hr change Synthamin 17 EF to:ml/hr

  • IF patient Nutrition Rate decreases, use table to increase Synthamin 17 EF rates.
  • IF patient Nutrition Rate drops to zero, increase Synthamin 17 EF to mls/h.
  • IF patients current type of nutritional support is changed (Ex. current Brand of EN or PN stopped/ new Brand added), print new Amino Acid Infusion Protocol Form using study web site: https://research.evidencebased.net/NephroCalc.
  • Recommend routine clinical evaluation and laboratory measurement of glucose, serum proteins, kidney and liver function tests, and serum electrolytes, as clinically appropriate.
For use in the Nephro-Protective Trial only. Created by Gordon S. Doig, Ver 1c, Last modified 7 May 2012, © EvidenceBased.net
BMI: Wt used for calcs:    Protein level used for calcs:
  • Commence Synthamin 17 EF at ml/hr continuously over 24 hrs via a central venous catheter. Note: Patient remains on this initial rate for entire ICU stay, unless Enteral or Parenteral Nutrition is started.


  • If Nutrition (EN or PN) is started, contact Research Coordinator to have study Synthamin 17 EF rates re-calculated or use the study web tool: https://Research.evidenceBased.net/nephroCALC.

For use in the Nephro-Protective Trial only. Created by Gordon S. Doig, Ver 1c, Last modified 7 May 2012, © EvidenceBased.net